Recall for incorrectly packaged flea product that could be fatal to cats.

It was with concern that I learned of an urgent recall by the Veterinary Medicines Directorate (VMD) of a flea product intended for tick and flea treatment in dogs that has, in unknown quantities been incorrectly packaged for cats and kittens.  The product is manufactured by Armitage Pet Care and the details can be found on the VMD website below:

https://www.gov.uk/government/news/armitage-pet-care-flea-and-tick-drops-for-dogs-and-armitage-flea-drops-for-cats-and-kittens-product-defect-alert

Working in busy general practice, every year I see several cats that have been poisoned by incorrectly applied over the counter flea products. The majority have been treated by their owners in error with spot-on products intended only for use in dogs.

Anyone who owns pets will understand the nuisance and distress an infestation of fleas can cause. In fact the most common species of flea found on both cats and dogs is Ctenocephalides felis felis, commonly known as the cat flea. The term ‘cat flea’ can however, cause confusion, as the name refers to the genus and species and not to fleas only isolated from cats. Not surprisingly, in my experience owners tend to be in a hurry to treat an infestation once it has been discovered. On the surface, over the counter products can appear to offer a cheap, more readily accessible alternative to the somewhat more expensive licensed products offered by vets.

So if dogs and cats can share the same fleas, why can’t they share the same treatment?

In the majority of cases, such as with the current product recall, the toxic component to cats is permethrin, a synthetic pyrethroid. Permethrin originates from a modified extract of the chrysanthemum flower. It is an insecticide, commonly used in spot-on preparations used control fleas, ticks, lice and ear mites. Insects are very sensitive to permethrin, in addition their lower body temperature increases the toxic effect making permethrin an effective insecticide. Cats can tolerate up to 0.1 per cent solutions well but the higher concentrations of 2 % or more found in some preparations for dogs are extremely toxic.

One theory behind why cats are so sensitive to permethrin is that as obligate carnivores they have no evolutionary requirement to metabolise plant based toxins. In herbivores and omnivores such as the dog for example an enzyme called glucoronyl transferase metabolises permethrin in the liver via a process called glucoronidation but in cats gene expression for the enzyme is believed to be faulty. It is the lack of this enzyme that also makes drugs like paracetamol so toxic to cats. Other chemicals added to flea products to improve efficacy may also block alternative metabolic pathways for permethrin in the cat. In addition permethrins are absorbed via the skin, however cats are fastidious about grooming and exposure is significantly increased by oral ingestion.

Permethrin is lipophilic (fat soluble) allowing it to distribute into fat and also cross the blood brain barrier, it accumulates in nervous tissue. Permethrin has a reversible effect on voltage gated sodium channels present in cell membranes. In nerve cells premethrin causes earlier depolarisation of the cell membrane generating repetitive firing of impulses known as ‘action potentials’ that travel to other nerves or stimulate muscle fibre contraction.

Over ninety percent of cats exposed to permethrin spot-on develop clinical signs after exposure. Onset of symptoms occur within 1-3 hrs, they include tremors, twitching, seizures and hyperthermia (as a result of increased muscular activity). Recovery can take 2- 3 days and in some cases longer. Breathing difficulties may develop secondary to muscle weakness. The effects can be fatal in 10% of cases.

Treatment consists of removal of the chemical and controlling the effects on the nervous system with muscle relaxants and anti-seizure medication whilst continuing supportive therapy like intravenous fluids to prevent dehydration. More recently however intralipid therapy has shown promise as a potential method of detoxification. Intralipids are sterile fat emulsions, traditionally used in human medicine to provide fat and energy intravenously to patients who are unable to eat for prolonged periods. In a toxicological context Intralipids were first used in people to reverse the toxic effects of local anaesthetics on the heart. Recently veterinarians have been using intralipid to treat lipohilic toxins like permethrin. Intralipids are thought to form a lipid sink for lipohilic drugs reducing the distribution of the drug within fats and nervous tissue and expediating recovery.

Having witnessed the dramatic and prolonged effects of permethrin toxicity first hand I would always urge pet owners to use flea products recommended by their vet.

References

J Feline Med Surg. 2007 Aug;9(4):335-9. Epub 2007 Jul 12. Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons Information Service (VPIS), London.Sutton NM1, Bates N, Campbell A.

Journal of Veterinary Emergency and Critical Care 22(6) 2012, pp 697–702 Use of intravenous lipid therapy in three cases of feline permethrin toxicosis Mark D. Haworth and Lisa Smart
Court MH & Greenblatt DJ (2000) Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics 10(4):355-369

Veterinary Clinics of North America November 2009 Volume 39, Issue 6, p993-1212 Small Animal Parasites: Biology and Control Edited by David S. Lindsay, Anne M. Zajac. Biology, Treatment and Control of Flea and Tick Infestations p1173-1200 B Blagburn, M Dryden

Consultations in Feline Internal Medicine, volume 6, edited by John R.August. Published by Saunders Elsevier. How to treat common parasites safely p390-398 by M Schwassman and D Logas

Small animal Critical Care Medicine edited by Deborah C Silverstein, Kate Hopper published by Saunders Elsevier. Pyrethrins. Manuel Boller Chapter 94 p394-398

Kirk’s Current Veterinary Therapy XV edited by John D Bonagura, David C Twedt. Over-the-Counter Drug Toxicosis Chapter 27 p115-120 D. Dorman.

Color atlas of physiology, 4th Edition by Agaemnon Despopulos and Stefan Silbergnagl published by Thieme

0 thoughts on “Recall for incorrectly packaged flea product that could be fatal to cats.”

  1. BruceJids says:
    Your comment is awaiting moderation. This is a preview, your comment will be visible after it has been approved.

    Easily create video subtitles that can be applied to karaoke songs or various other media, with this comprehensive piece of software

    Press the “Download Now” button to download Sayatoo SubtitleMaker crack only.
    The whole process will just take a few moments.

    Mirror Link —> Sayatoo SubtitleMaker crack keygen for windows

    – Version: 2.3.8.5528
    – Developer: Sayatoo Technology, Inc.
    – Downloads: 465
    – Download type: safety (no torrent/no viruses)
    – Status file: clean (as of last analysis)
    – File size: undefined
    – Price: free
    – Special requirements: no requirements
    – Home page: esd.element5.com/affiliate.html?affiliateid=70900&publisherid=200063255&target=http%3a%2f%2fen.sayatoosoft.com%2findex_en.html
    – Rating:

    Tags:
    Sayatoo SubtitleMaker activator
    Sayatoo SubtitleMaker keygen serial
    Sayatoo SubtitleMaker crack latest
    Sayatoo SubtitleMaker Full Patched
    Sayatoo SubtitleMaker + Full Crack

    Popular software:
    Website Auto Traffic Generator Ultimate + Full Crack
    Simple Disable Key With License Key Latest
    RapidMiner Studio Full Patched
    FPS Monitor crack new
    SUPERPOSITION Benchmark key crack
    Пройти Антиплагиат курсовая
    Oh, My! Tomato Pie! – Healthy Vegetarian Diets
    Convert Google books to PDF, PNG or JPG
    скачать видео с одноклассники
    CPDB divulga cursos tecnicos na OSSJB | OSSJB Campinas
    Готовые ответы и знания к учебникам и рабочим тетрадям по предметам школьного курса за 5-11 класс

  2. BruceJids says:
    Your comment is awaiting moderation. This is a preview, your comment will be visible after it has been approved.

    Press the “Download Now” button to download EaseUs Disk Copy Home Edition activator.
    The whole process will just take a few moments.

    Mirror Link —> EaseUs Disk Copy Home Edition Cracked Latest

    Portable application that enables users to easily copy a hard drive to another location, whether it’s a USB flash disk, CD/DVD drive, or ISO image

    · Build: 3.0 Build 20180503
    · Company: Chengdu Yiwo Tech Development
    · Downloads: 520
    · Download type: safety (no torrent/no viruses)
    · File status: clean (as of last analysis)
    · File size: undefined
    · Price: 0
    · Special requirements: no requirements
    · User rating:

    Tags cloud:
    easeus disk copy home edition crack, easeus disk copy home edition crack keygen serial, easeus disk copy home edition with crack, easeus disk copy home edition crack patch, easeus disk copy home edition crack serial number, easeus disk copy home edition keygen crack patch, easeus disk copy home edition crack patch, easeus disk copy home edition patch, easeus disk copy home edition full version with keys latest, easeus disk copy home edition serial keys x86/x64

    It may be interesting:
    Security Monitor Pro Crack Latest Version
    Cypheros TS-Doctor full crack
    PC SpeedCat Keygen Crack
    уникальность текста бесплатно
    New school uses computer science to teach big topics and big thinking | NEOSTEM
    Download Football Manager 2010 crack and keygen free download
    tool for downloading Google books
    how to download video from facebook
    Hello world! – Un Mundo De Tecnologia
    готовые домашние задания и решебники
    Windows Software Cracks
    Download dc_wff.dll to fix missing or corrupted DLL errors

  3. BruceJids says:
    Your comment is awaiting moderation. This is a preview, your comment will be visible after it has been approved.

    Press the “Download Now” button to download memoQ Keygen Crack.
    The whole process will just take a few moments.

    Mirror Link —> memoQ license crack

    You can translate documents better and faster, with support for an extensive amount of languages offered by this complex yet intuitive application

    · Build: 8.7.10
    · Company: Kilgray
    · Downloads: 711
    · Download type: safety (no torrent/no viruses)
    · File status: clean (as of last analysis)
    · File size: undefined
    · Price: free
    · Special requirements: no
    · User rating:

    Tags:
    memoq crack hack, memoq crack windows, memoq serial key, memoq keygen crack, memoq serial code, memoq crack keygen for windows, memoq crack fix, memoq full crack latest, memoq serial number, memoq activate code

    Other useful resources:
    Elcomsoft eXplorer for WhatsApp keygen crack patch
    Stellar Phoenix Word Repair crack and keygen free download
    Kutools for Outlook crack keygen serial
    Антиплагиат поможем пройти
    Hello world! – A WordPress Site
    Download Quern – Undying Thoughts Full Version With Keys Latest
    tool for downloading Google books
    free video downloader online
    Purevpn For Chrome – App To For Back
    ГДЗ для школы
    Software Cracks Keygens
    How to repair missing or corrupt crtdll.dll

  4. BruceJids says:
    Your comment is awaiting moderation. This is a preview, your comment will be visible after it has been approved.

    Push the “Download Now” button to download Epubor VitalSource Downloader crack keygen serial.
    The whole process will just take a few moments.

    Circumvent VitalSource DRM restrictions with the help of this converter that makes all your books available on all your devices in no time

    Mirror Link —> Epubor VitalSource Downloader Crack Patch

    · Version: 1.0.10.252
    · Crack date: Jan 28th 2019
    · Developer: Epubor
    · Downloads: 14935
    · Download type: safety (no torrent/no viruses)
    · Status: clean (as of last analysis)
    · File size: na
    · Price: 0
    · Special requirements: no
    · Supported systems: Windows 10 64 bit, Windows 10, Windows 8 64 bit, Windows 8, Windows 7 64 bit, Windows 7
    · User rating:

    Keywords:
    epubor vitalsource downloader crack serial number, epubor vitalsource downloader activate code, epubor vitalsource downloader licence keys, epubor vitalsource downloader full version serial keys latest, epubor vitalsource downloader keygen serial, epubor vitalsource downloader crack patch, epubor vitalsource downloader serial key, epubor vitalsource downloader keygen serial, epubor vitalsource downloader crack latest version, epubor vitalsource downloader keygen free download

    Popular software: here

  5. BruceJids says:
    Your comment is awaiting moderation. This is a preview, your comment will be visible after it has been approved.

    Press the “Download Now” button to download Smallpdf crack keygen for windows.
    It will just take a few seconds.

    Compress PDF docs to reduce file size or convert them to Word, Excel, PowerPoint or JPG without other dependencies using this stylish tool

    MIRROR —> https://crackserialnumber.com/crack/smallpdf-112354

    · Version: 1.24.0
    · Release date: Dec 24th 2018
    · Developer: Smallpdf GmbH
    · Downloads: 30906
    · Download type: safety (no torrent/no viruses)
    · Status: clean (as of last analysis)
    · File size: unknown
    · Price: no cost
    · Special requirements: no requirements
    · Systems: Windows 10 64 bit, Windows 10, Windows 8 64 bit, Windows 8, Windows 7 64 bit, Windows 7
    · Rating:

    Tags cloud:
    smallpdf crack windows, smallpdf crack install, smallpdf crack patch, smallpdf crack version, smallpdf cracked latest, smallpdf + crack, smallpdf update crack, smallpdf crack and keygen free download, smallpdf crack install, smallpdf crack patch

    More software: this way

    It may be interesting:
    Антиплагиат как пройти
    Margarita Fuster. – Necesitas algo de Chanel
    Download Ducati World Racing Challenge license
    Letter of good conduct and recommendation | J.T. Shim
    EDS Google Books Downloader – download google books free
    Blog Post Title – Alden Adams
    Готовые ответы и знания к учебникам и рабочим тетрадям по предметам школьного курса за 5-11 класс
    Holiday Portrait Sessions
    Repair missing or corrupt qt5opengl.dll

  6. BruceJids says:
    Your comment is awaiting moderation. This is a preview, your comment will be visible after it has been approved.

    Push the “Download Now” button to download Construct 2 + Crack Latest.
    The process will just take a few seconds.

    Easily develop 2D video games without coding experience, thanks to this intuitive gaming engine that has a drag-and-drop visual editor

    MIRROR —> https://crackdownloadz.com/app/construct-2/14205

    · Release version: r272
    · Crack date: September 9 2019
    · Developer: Scirra
    · Downloads: 29896
    · Download type: safety (no torrent/no viruses)
    · Status: clean (as of last analysis)
    · File size: small
    · Price: gratis
    · Special requirements: no
    · Systems: Win 10 64 bit / Win 10 / Win 8 64 bit / Win 8 / Win 7 64 bit / Win 7
    · User rating:

    Tags:
    construct 2 full crack latest, construct 2 crack install, construct 2 crack fix, construct 2 + crack latest, construct 2 cracked full, construct 2 update crack, construct 2 serial number, construct 2 activate code, construct 2 crack serial number, construct 2 + crack

    More keygens: here

    More software:
    Sorties kayak et traversees a pied dans la baie du Mont Saint Michel et les Iles Chausey – Kayaklabaie
    Как обмануть антиплагиат бесплатно
    Enhanced Lips with Dermal Fillers – Lip Filler Injections & Lip Enhancement Perth.
    Download Ken Follett’s The Pillars of the Earth: Book Three + Full Crack
    Witamy! | ZAKLAD FILOZOFII POLITYKI
    tool for downloading Google books
    Скачать AbsoluteTelnet / SSH серийный ключ и кряк
    Download ext-ms-win-winbici-l1-1-0.dll to fix missing or corrupted DLL errors
    Community Funding > Grants for Groups and Charities in Scotland

Leave a Reply

Your email address will not be published. Required fields are marked *